CY-09, ≥98%
综合评分
- 商品
5分 - 服务
5分 - 物流
5分
热销商品排行
| CAS | 1073612-91-5 |
|---|---|
| 英文名称 | CY-09 |
| 别名 | ；QuetiapineS-oxidedihydrochloride |
| 纯度 | ≥98% |
| 分子量 | 423.43 |
| 外观（性状） | Light yellow to yellow Solid |
| 储存条件 | Powder : 2-8℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| MDL | MFCD31619349 |
| SMILES | OC(C1=CC=C(/C=C2SC(N(CC3=CC=CC(C(F)(F)F)=C3)C\2=O)=S)C=C1)=O |
| 描述 | 一种特异的NLRP3 inflammasome的抑制剂,直接靶向NLRP3。(It is a specific inhibitor of the NLRP3 inflammasome that directly targets NLRP3.) |
| 靶点 | NOD-like Receptor (NLR) |
| 通路 | Immunology & Inflammation |
| 生物活性 | CY-09是一种特异的NLRP3 inflammasome的抑制剂，直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 μM。[1] |
| In Vitro | CY-09 specifically blocks NLRP3 activation in macrophages. CY-09 inhibits NLRP3 oligomerization and inflammasome assembly. CY-09 directly binds to NLRP3 and inhibits its ATPase activity. The metabolic stability of CY-09 was first evaluated using human and mouse liver microsomes, exhibiting favorable stability with the half-life >145 min for both human and mouse microsomes. The metabolic stability of CY-09 was first evaluated using human and mouse liver microsomes, exhibiting favorable stability with the half-life >145 min for both human and mouse microsomes, which exhibited low risk of drug-drug interactions[1]. |
| In Vivo | CY-09 inhibits NLRP3 activation in vivo and prevents neonatal lethality in a mouse model of CAPS. In pharmacokinetic studies evaluted in C57BL/6J mice administered a single i.v. or oral dose, CY-09 exhibits favorable pharmacokinetics, with a half-life of 2.4 h, an area under the curve of 8,232 (h·ng)/ml, and bioavailability of 72%. CY-09 reverses metabolic disorders in diabetic mice by inhibition of NLRP3-dependent inflammation. CY-09 treatment has remarkable beneficial effects for metainflammation, hyperglycemia, and insulin resistance in diabetic mice[1]. |
| 细胞实验 | 5 × 105/ml BMDMs and 6 × 106/ml PBMCs were plated in 12-well plates. The following morning, the medium was replaced, and cells were stimulated with 50 ng/ml LPS or 400 ng/ml Pam3CSK4 (for noncanonical inflammasome activation) for 3 h. After that, CY-09 or other inhibitors were added into the culture for another 30 min, and then the cells were stimulated for 4 h with MSU (150 μg/ml), Salmonella typhimurium (multiplicity of infection) or for 30 min with ATP (2.5 mM) or nigericin (10 μM). Cells were transfected with poly(dA:dT) (0.5 μg/ml) for 4 h or LPS (500 ng/ml) overnight. Cell extracts and precipitated supernatants were analyzed by immunoblot.[1] |
| 动物实验 | Animal Models: C57BL/6J mice; Dosages: 5 and 10 mg/kg; Administration: i.v. and oral administration[1] |
| 数据来源文献 | [1] Jiang H, et al. J Exp Med. 2017, 214(11):3219-3238. |
| 规格 | 5mg10mg |
| 单位 | 瓶 |
售后保障
1.售后服务
幺米Lab自营店铺销售的商品，由平台提供电子发票或纸质发票和相应的售后服务。确保为原厂正货！保证与当时市场上同样主流产品一致。请您放心购买！
入驻店铺销售的商品，由入驻商家提供发票和相应的售后服务。
如您购物环节遇到任何问题，请第一时间联系客服人员，我们会尽心为您处理问题。
2.退换货说明
用户在收到货物后请立即检验产品包裹，若发现任何包装规格、数量、品种不符，外观毁损、短缺或缺陷，请在2个工作日内将能说明相关问题的产品外观照片，反馈给我方客户服务部，我们会第一时间核实具体情况，为您办理退换货。
如果你在使用产品的过程中，遇到产品内在质量的问题，请在7个工作日内，将产品的外观照片，检测数据，测试谱图等能说明产品确实存在质量问题的证据，反馈给我司客服人员，我们会对产品的证据进行核实判断，尽快给出处理结果，如若产品确实存在质量问题，我们会在第一时间为您办理退换货。
若因客户个人原因导致的退换货，须经我方售后客服人员核实确认，在确保产品可以进行二次销售的前提下，我们会为您办理退换货，我们将收取产品成交价的20%的手续费。
详情参见售后说明
3.关于发货
幺米委托第三方快递公司为客户提供送货上门服务，客户无须向快递公司支付额外的费用。
入驻商家发货的订单，如您有特殊需求，可以联系商家协商发货快递。
